Get multi-symptom estrogen decline relief. Guaranteed.

Equelle is a revolutionary supplement clinically studied to provide relief for hot flashes, poor sleep quality, muscle aches, and more.1-5‡⁋
Try it today or take our quiz to find out if Equelle is right for you.

Friends holding Equelle

No prescription required

Plant-based S-equol

Hormone-Free

Estrogen Decline Symptom Relief Supplement†

2427 Reviews

as low as $37 / month

Hormone-Free*, non-prescription multi-symptom menopause relief†.

  • Powered by S-equol, a safe & effective plant-based ingredient1-4,7
  • Key ingredient backed by decades of scientific research7
  • Take 2 tablets daily for multi-symptom relief†
  • Over 1500 5 star reviews
  • Achieve results in 90 days or less or get your money back**

Estrogen Decline Affects More Than You Think

What menopausal symptoms are you dealing with?

Click below to find out how Equelle can help

Experience fewer hot flashes per day 1,2†

Equelle is clinically studied to help reduce the frequency of daily hot flashes within 90 days or less

Get menopause symptom relief or get your money back

The Power of S-equol

S-equol is backed by 20+ Years of Scientific Research 7

Equelle’s key ingredient, S-equol, works by mimicking estrogen. As estrogen declines menopause symptoms can increase. S-equol mimics estrogen in your body to help relieve menopause symptoms.†

Get menopause symptom relief or get your money back

Trusted by healthcare professionals

"I confidently recommend Equelle to my patients seeking relief from menopausal symptoms. Its clinically studied ingredient offers a solution that many women find incredibly beneficial."
Dr. James A. Simon, MD, CCD, MSCP, IF, FACOG
Equelle Medical Partner

Take our quick and easy quiz to find out if Equelle is right for you today.

Equelle has helped thousands of women find relief

“I just started my third month, and WOW! Symptoms are almost completely gone! This is the first product that has actually worked!...”

Shannon R., 50-54

Verified Customer

“I love this product as it has been a complete game changer in my life. Initially I was taking a competitor’s brand and not seeing any results… I am religious about taking it every day and I can definitely tell a huge difference. I will NOT go without this product. THANK YOU!”

Carrie A., 50-54

Verified Customer

“Wow! After only a few months, my hot flashes have almost disappeared! I’m so impressed with this product!! My gyno recommended it.”

Lisa H., 50-54

Verified Customer

Join the thousands of women who rely on Equelle for multi-symptom relief

As seen in

We're based in La Jolla, CA
4250 Executive Square,
La Jolla, CA 92037

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* Free from human or animal hormones. Contains trace amounts of plant isoflavones.

‡ Significant vs baseline and not placebo

⁋ Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI)

** Our 90-day Money Back Guarantee is designed to give you the opportunity to try Equelle risk-free, as results may take up to 2-3 months to notice. If you haven’t found relief by the end of your third month with Equelle, you can request a full refund for up to three bottles. To take advantage of this guarantee, simply email our customer support team at hello@equelle.com within 120 days of your purchase date

1. Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt). 2012;21(1):92-100. doi:10.1089/jwh.2011.2753

2. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt). 2012;21(6):674-682. doi:10.1089/jwh.2011.3153

3. Data on File. 1811 Study Report; Pharmavite LLC.

4. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial: A pilot randomized, placebo-controlled trial. Menopause. 2011;18(5):563-574. doi:10.1097/gme.0b013e3181f85aa7

5. National Institutes of Health, Office of Dietary Supplements. Calcium: Fact Sheet for Health Professionals. 2024. https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional

6. Daily JW, Ko BS, Ryuk J, Liu M, Zhang W, Park S. Equol decreases hot flashes in postmenopausal women: A systematic review and meta-analysis of randomized clinical trials. J Med Food. 2019;22(2):127-139. doi:10.1089/jmf.2018.4265

7. Utian WH, Jones M, Setchell KDR. S-equol: a potential nonhormonal agent for menopause-related symptom relief. J Womens Health (Larchmt). 2015;24(3):200-208. doi:10.1089/jwh.2014.500