Get multi-symptom menopause relief in one supplement.Guaranteed.

Equelle is a revolutionary supplement clinically studied to provide relief for hot flashes, mood swings, vaginal irritation, and more. Try it today or take our quiz to find out if Equelle is right for you.†1,2

No prescription required

Plant-based S-equol

Hormone-Free

Estrogen Decline Symptom Relief Supplement†

2427 Reviews

as low as $37 / month

Hormone-Free*, non-prescription multi-symptom menopause relief.

  • Plant-based relief, powered by S-equol
  • Key ingredient backed by decades of safety & efficacy research3,4,5
  • Take 2 tablets, once daily, for multi-symptom relief†
  • Over 1500 5 star reviews
  • Achieve results in 90 days or less or get your money back6

Estrogen Decline Affects More Than You Think

What menopausal symptoms are you dealing with?

Click below to find out how Equelle can help

Experience 5 fewer hot flashes per day †1**

Equelle is clinically studied to help reduce the frequency of daily hot flashes within 90 days or less

Get menopause symptom relief or get your money back

The Power of S-equol

S-Equol is backed by 20+ Years of Scientific Research 3,4,5

Equelle's key ingredient, S-equol, works by safely and naturally mimicking estrogen. As estrogen declines menopause symptoms can increase. S-equol mimics estrogen in your body to help relieve menopause symptoms.†

Get menopause symptom relief or get your money back

Recommended by over 1,500 healthcare professionals

"I’ve been recommending Equelle to my patients for years. It improves sleep, with fewer hot flashes and less vaginal irritation."
Nurse Barb Dehn, Certified Menopause Practitioner
Equelle Medical Partner

Take our quick and easy quiz to find out if Equelle is right for you today.

Equelle has helped thousands of women find relief

“I just started my third month, and WOW! Symptoms are almost completely gone! This is the first product that has actually worked!...”

Shannon R., 50-54

Verified Customer

“I love this product as it has been a complete game changer in my life. Initially I was taking a competitor’s brand and not seeing any results… I am religious about taking it every day and I can definitely tell a huge difference. I will NOT go without this product. THANK YOU!”

Carrie A., 50-54

Verified Customer

“Wow! After only a few months, my hot flashes have almost disappeared! I’m so impressed with this product!! My gyno recommended it.”

Lisa H., 50-54

Verified Customer

Join the thousands of women who rely on Equelle for multi-symptom relief

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We're based in La Jolla, CA
4250 Executive Square,
La Jolla, CA 92037

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* Free from human or animal hormones. Contains trace amounts of plant isoflavones.

‡ Supports vascular health as you age

⁋ Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which is a 19-item questionnaire designed to measures sleep disturbance. A higher score on the PSQI indicates greater sleep disturbances.

** In patients with >8 hot flashes at baseline (P=0.63 vs isoflavones)

# Sleep minutes were calculated using the Motionlogger Micro Watch (a wearable sleep tracker) that patients wore at home for a week at a time to measure changes in sleep.

|| In a multicenter, double-blind, placebo-controlled trial, 118 perimenopausal or menopausal women were randomized to receive EQUELLE or placebo for up to 12 weeks.

§ Data on file. In-Home Usage Test. Pharmavite LLC.

1. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency.

2. Data on File. 1811 Study Report; Pharmavite LLC

3. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized placebo-controlled trial. Menopause. 2011;18(5):563-574.

4. Utian WH, Jones M, Setchell KDR. J Women’s Health (Larchmt). 2015;24(3):200-208. http://doi.org/1089/jwh.2014.5006.

5. Tempfer CB, Froese G,Heinze G, Bentz EK, Hefler LA, Huber JC. Side effects of phytoestrogens: a meta-analysis of randomized trials. Am J Med. 2009;122(10):939-46.e9, J Nutr. 2009;139(5):981-986.

6. Our 90-day Money Back Guarantee is designed to give you the opportunity to try Equelle risk-free, as results may take up to 2-3 months to notice. If you haven’t found relief by the end of your third month with Equelle, you can request a full refund for up to three bottles. To take advantage of this guarantee, simply email our customer support team at hello@equelle.com within 120 days of your purchase date